On Sunday, Reading striker Yakou Meite called out racist abuse sent via social media after his spot-kick was saved.
Last week, Chelsea condemned “abhorrent posts” aimed at Tammy Abraham after his Super Cup final miss against Liverpool.
Blues boss Frank Lampard said he was “disgusted” by the abuse aimed at the 21-year-old England forward and suggested social media companies must do more to stop players being targeted.
Ivory Coast forward Meite, 23, came on as a substitute against Cardiff and missed a 91st-minute penalty.
Others fans quickly condemned the tweets containing racist abuse that was sent to Pogba – who won the penalty he then missed – shortly after full-time at Molineux on Monday.
Some tweets were later deleted while several accounts appeared to have been taken down.
Twitter’s terms and conditions say it “takes action against behavior that targets individuals with hateful conduct”.
In July, anti-racism charity Kick It Out produced a report that showed reports of racist abuse increased by 43% last season, with 274 cases compared with 192 the previous season.