Sunderland played with 10 men for more than 45 minutes after Sebastian Larsson‘s controversial red card for a challenge on Ander Herrera.
Zlatan Ibrahimovic had already put United ahead with a sublime, curling 20-yard effort.
Henrikh Mkhitaryan made it 2-0 before Marcus Rashford drilled in the third.
Watch goal moments below:
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