Ighalo sustained a hamstring injury in Changchun Yatai’s game against Tianjin Quianjian on Wednesday.
The five-goal hero in the two-legged AFCON qualification games against Libya in October was stretchered off the pitch in the 16th minute.
Ighalo disclosed to TheCable that it’s a hamstring injury.
“I pulled my hamstring,” Ighalo said.
The extent of his hamstring will be determined after a scan which will be carried out later.
The Super Eagles will take on the Bafana Bafana on November 17 in Johannesburg.
It takes up to three weeks for a player to recover from a hamstring injury.